Did you know that estrogen can be metabolized by several pathways into different metabolites?
- 2-Hydroxyestrone metabolite – weaker estrogen receptor binding affinity, protective
- 16α-Hydroxyestrone metabolite – strong estrogenic activity, stimulates estrogen receptor
- 4-Hydroxyestrone metabolite – potent, can oxidize to quinones; potentially pro-carcinogenic
Estrogen metabolized to 4-OHE1(E2) can lead to the formation of DNA adducts. This process is a putative tumor initiating event. Advanced hormone testing can help Dr. Moore better understand a patient’s hormone levels as well as their metabolites. Certain natural medicines can be helpful in supporting healthier estrogen metabolism to aid in cancer prevention, as well as the treatment of uterine fibroids, peri-menopausal symptoms and other conditions. (Reprod Biol Endocrinol. 2010; 8: 93. Biochim Biophys Acta. 2006 Aug;1766(1):63-78.)